Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome
Identifieur interne : 005508 ( Main/Exploration ); précédent : 005507; suivant : 005509Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome
Auteurs : V. C. C. Cheng [République populaire de Chine] ; I. F. N. Hung [République populaire de Chine] ; B. S. F. Tang [République populaire de Chine] ; C. M. Chu [République populaire de Chine] ; M. M. L. Wong [République populaire de Chine] ; K. H. Chan [République populaire de Chine] ; A. K. L. Wu [République populaire de Chine] ; D. M. W. Tse [République populaire de Chine] ; K. S. Chan [République populaire de Chine] ; B. J. Zheng [République populaire de Chine] ; J. S. M. Peiris [République populaire de Chine] ; J. J. Y. Sung [République populaire de Chine] ; K. Y. Yuen [République populaire de Chine, Hong Kong]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Diarrhée (étiologie), Femelle, Flambées de maladies, Humains, Mâle, Partie nasale du pharynx (virologie), Réplication virale, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie), Études rétrospectives.
- MESH :
- pathogénicité : Virus du SRAS.
- physiologie : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- virologie : Partie nasale du pharynx, Syndrome respiratoire aigu sévère.
- étiologie : Diarrhée.
- Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Humains, Mâle, Réplication virale, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Comparative study, Coronavirus, Critically ill, Diarrhea, Diarrhea (etiology), Disease Outbreaks, Female, Gastrointestinal, Human, Humans, Male, Microbiological investigation, Middle Aged, Mortality, Nasopharynx, Nasopharynx (virology), Pathogenesis, Prognosis, Replication, Retrospective Studies, SARS Virus (pathogenicity), SARS Virus (physiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Standards, Symptomatology, Treatment, Virus Replication.
- MESH :
- etiology : Diarrhea.
- pathogenicity : SARS Virus.
- physiology : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Nasopharynx, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Disease Outbreaks, Female, Humans, Male, Middle Aged, Retrospective Studies, Virus Replication.
Abstract
The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. Data from daily hematological, biochemical, radiological, and microbiological investigations were prospectively collected, and the correlation of these findings with diarrhea was retrospectively analyzed. Sixty-nine patients (48.6%) developed diarrhea at a mean (± standard deviation [SD]) of 7.6 ± 2.6 days after the onset of symptoms. The diarrhea was most severe at a mean (±SD) of 8.8 ± 2.4 days after onset, with a maximum frequency of 24 episodes per day (median, 5 episodes; range, 3–24 episodes). A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log10 vs. 1.8 log10 copies/mL; P = .01) and mortality (6.2 vs. 1.7 log10 copies/mL; P < .01). However, diarrhea was not associated with mortality. The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. Additional investigation of the role of SARS coronavirus in the pathogenesis of diarrhea in patients with SARS should be conducted.
Url:
DOI: 10.1086/382681
Affiliations:
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C. C." last="Cheng">V. C. C. Cheng</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Hung, I F N" sort="Hung, I F N" uniqKey="Hung I" first="I. F. N." last="Hung">I. F. N. Hung</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Tang, B S F" sort="Tang, B S F" uniqKey="Tang B" first="B. S. F." last="Tang">B. S. F. Tang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C. M." last="Chu">C. M. Chu</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine, United Christian Hospital</wicri:regionArea><wicri:noRegion>United Christian Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Wong, M M L" sort="Wong, M M L" uniqKey="Wong M" first="M. M. L." last="Wong">M. M. L. Wong</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Geriatrics, Caritas Medical Centre</wicri:regionArea><wicri:noRegion>Caritas Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A. K. L." last="Wu">A. K. L. Wu</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Tse, D M W" sort="Tse, D M W" uniqKey="Tse D" first="D. M. W." last="Tse">D. M. W. Tse</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Geriatrics, Caritas Medical Centre</wicri:regionArea><wicri:noRegion>Caritas Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K. S." last="Chan">K. S. Chan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine, United Christian Hospital</wicri:regionArea><wicri:noRegion>United Christian Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, B J" sort="Zheng, B J" uniqKey="Zheng B" first="B. J." last="Zheng">B. J. Zheng</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J. Y." last="Sung">J. J. Y. Sung</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Infection, Queen Mary Hospital, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country><wicri:regionArea>Reprints or correspondence: Prof. K. Y. Yuen, Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2004</date><biblScope unit="vol">38</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="467">467</biblScope><biblScope unit="page" to="475">475</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Comparative study</term><term>Coronavirus</term><term>Critically ill</term><term>Diarrhea</term><term>Diarrhea (etiology)</term><term>Disease Outbreaks</term><term>Female</term><term>Gastrointestinal</term><term>Human</term><term>Humans</term><term>Male</term><term>Microbiological investigation</term><term>Middle Aged</term><term>Mortality</term><term>Nasopharynx</term><term>Nasopharynx (virology)</term><term>Pathogenesis</term><term>Prognosis</term><term>Replication</term><term>Retrospective Studies</term><term>SARS Virus (pathogenicity)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Standards</term><term>Symptomatology</term><term>Treatment</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diarrhée (étiologie)</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Partie nasale du pharynx (virologie)</term><term>Réplication virale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (pathogénicité)</term><term>Virus du SRAS (physiologie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Diarrhea</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Partie nasale du pharynx</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasopharynx</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Diarrhée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Réplication virale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Diarrhée</term><term>Etude comparative</term><term>Exploration microbiologique</term><term>Forme grave</term><term>Gastrointestinal</term><term>Homme</term><term>Malade état grave</term><term>Mortalité</term><term>Nasopharynx</term><term>Norme</term><term>Pathogénie</term><term>Pronostic</term><term>Réplication</term><term>Symptomatologie</term><term>Syndrome respiratoire aigu sévère</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Mortalité</term><term>Norme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. Data from daily hematological, biochemical, radiological, and microbiological investigations were prospectively collected, and the correlation of these findings with diarrhea was retrospectively analyzed. Sixty-nine patients (48.6%) developed diarrhea at a mean (± standard deviation [SD]) of 7.6 ± 2.6 days after the onset of symptoms. The diarrhea was most severe at a mean (±SD) of 8.8 ± 2.4 days after onset, with a maximum frequency of 24 episodes per day (median, 5 episodes; range, 3–24 episodes). A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log10 vs. 1.8 log10 copies/mL; P = .01) and mortality (6.2 vs. 1.7 log10 copies/mL; P < .01). However, diarrhea was not associated with mortality. The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. Additional investigation of the role of SARS coronavirus in the pathogenesis of diarrhea in patients with SARS should be conducted.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V. C. C." last="Cheng">V. C. C. Cheng</name></noRegion><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K. S." last="Chan">K. S. Chan</name><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C. M." last="Chu">C. M. Chu</name><name sortKey="Hung, I F N" sort="Hung, I F N" uniqKey="Hung I" first="I. F. N." last="Hung">I. F. N. Hung</name><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J. Y." last="Sung">J. J. Y. Sung</name><name sortKey="Tang, B S F" sort="Tang, B S F" uniqKey="Tang B" first="B. S. F." last="Tang">B. S. F. Tang</name><name sortKey="Tse, D M W" sort="Tse, D M W" uniqKey="Tse D" first="D. M. W." last="Tse">D. M. W. Tse</name><name sortKey="Wong, M M L" sort="Wong, M M L" uniqKey="Wong M" first="M. M. L." last="Wong">M. M. L. Wong</name><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A. K. L." last="Wu">A. K. L. Wu</name><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name><name sortKey="Zheng, B J" sort="Zheng, B J" uniqKey="Zheng B" first="B. J." last="Zheng">B. J. Zheng</name></country><country name="Hong Kong"><noRegion><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name></noRegion><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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